Methodological Issues Research Articles

Mapping scoping reviews in neurosurgery: a scoping review protocol

IntroductionThe realm of neurosurgery is currently witnessing a surge in primary research, underscoring the importance of adopting evidence-based approaches. Scoping reviews, as a type of evidence synthesis, offer a broad...

Effects of work-directed interventions on return-to-work in people on sick-leave for to common mental disorders-a systematic review.

To evaluate the body of evidence of the effects of work-directed interventions on return-to-work for people on sick leave due to common mental disorders (i.e., mild to moderate depression, anxiety, adjustment disorders and reactions to severe stress). The systematic review was conducted in accordance with an a priori developed and registered protocol (Prospero CRD42021235586). The certainty of evidence was assessed by two independent reviewers using the Grading of Recommendations, Assessment, Development and Evaluations. We reviewed 14,794 records published between 2015 and 2021. Of these, eight RCTs published in eleven articles were included in the analysis. Working age adults (18 to 64years), on sick leave due to mild to moderate depression, anxiety, adjustment disorders or reactions to severe stress. Work-directed interventions. No comparator, Standard care, or other measures. return to work, number of days on sick leave, income. Overall, the effects of work-focused CBT and work-focused team-based support on RTW resulted in increased or faster return-to-work compared with standard care or no intervention (low certainty of evidence). The effects of Individual Placement and Support showed no difference in RTW compared with standard care (very low certainty of evidence). Interventions involving the workplace could increase the probability of RTW. Areas in need of improvement in the included studies, for example methodological issues, are discussed. Further, suggestions are made for improving methodological rigor when conducting large scale trials.

A review of published studies on virtual reality in sexuality research.

Virtual reality (VR) technology contributes to greater approach of methodological safety to make ecological validity more feasible and a growing interest in sexuality behaviors. The aim of this study was to show VR in the sexuality area by a comprehensive review of outcomes, offer a synthesis of the studies, and make a methodological quality assessment of finding results. A secondary goal was to investigate the effect of immersion on diverse sexual responses outcomes. We designed a review based on a systematic review strategy describing types of studies, participants, data collection and outcomes; searched in 4 electronic databases (PubMed, EMBASE, PsycINFO, and SciELO), and made a full-text screening process. The study found 18 articles that met research criteria synthesized within 3 outcome groups: erection measures, level of immersion, and biomarker studies. Synthesis shows a lack of methodological aspects that impair results, such as description of methods from bias protection, randomization, or concealment. The literature still needs to improve its methodology, even though it already shows relevant data for intervention in sexual dysfunction, forensic psychiatry, sexual attraction, orientation, and use of pornography. Current methodological issues need better design to highlight relevant issues in sexuality with stronger quality of design, opening boundaries to new diagnostic or interventional technologies to sexual health.

Environmental data and scores: Lost in translation

AbstractThis paper investigates methodological issues and limited coverage of providers' environmental scores, which are increasingly employed by investors, financial institutions and policymakers for corporate environmental assessment. The contribution of the paper is twofold. First, regression analysis shows a substantial heterogeneity among the environmental scores of seven providers in the reliance on raw data. However, as some variables are found meaningful across providers, the request to enhance disclosure should focus on such variables. The heterogeneity of the unexplained component of the regression across providers can be arguably referred to as judgemental factors and underlines the providers' different focus on financial risk or environmental impact. Second, we propose a classification system based on corporate disclosure data that aims to enable investors to extend the environmental assessment of companies not rated by providers. This system has been calibrated to implement two common investment strategies, that is, best‐in‐class and exclusion and allows to build portfolios with both environmental and financial profiles similar to portfolios based on providers' scores. The work aims to contribute to the intersection between the analysis of methodologies of E‐scores and their practical use for investment purposes. Rather than asking for a mirage of full comparability of E‐scores, the paper substantiates that is of utmost importance to improve the disclosure of corporate data to enhance the environmental assessment as well as the transparency on providers' methodologies to enable investors to select E‐scores consistent with their risk‐impact preferences. Such transparency will foster the development of sustainable finance.

Strong and Weak Theories of Capacity: Eve Kosofsky Sedgwick, Disability, and Contemporary Capacity Theorizing

Abstract This article puts forward two ways of understanding capacity: strong and weak theories. The strong theory of capacity self-evidently connects capacity with ideal humanity or pedestalizes it as an analytic concept, while the weak theory of capacity allows space for interpretations about life unfolding without murmurings about capacity. By considering capacity in a way that distinguishes these two theories, the article contributes to contemporary thinking in which capacity has emerged as a key concept. My perspective draws on Eve Kosofsky Sedgwick’s ideas about strong and weak theories and is further influenced by methodological issues raised by disability studies scholars. I first recall Sedgwick’s ideas about strong theories, after which I focus on how capacity assumptions operate in Silvan Tomkins’ work, which has had an important impact on Sedgwick. I then identify two recent contributions in disability studies in the area of capacity-themed theorizing. I interrogate the ways in which these contributions share the habits of the strong theory and how they escape its problematic tendencies. Toward the end of the article, I outline how the weak theory of capacity could contribute new perspectives to the contemporary discussion.

Methodological Proposals for Developing Trustworthy Recommendations of Integrative Chinese-Western Medicine

AimTo refine the methods of developing clinical practice guidelines (CPGs) for integrative Chinese-Western medicine (ICWM), promoting the formation of trustworthy, implementable recommendations that integrate the strengths of Chinese and Western medicine. MethodsUsing a nominal group technique (NGT) approach, a multidisciplinary expert panel was established. The panel identified key methodological issues in ICWM-CPG development through literature review and iterative discussions, and formulated methodological proposals to address these issues. The final set of proposals was achieved through consensus among the panel members. ResultsThe collaborative effort resulted in the identification of five pivotal methodological issues and the subsequent establishment of 22 specific recommendations. These encompass strict adherence to renowned standards, such as those proposed by the Institute of Medicine (IOM) and Guidelines International Network (G-I-N), the employment of methodologies like the GRADE approach and RIGHT statement, the strategic constitution of a balanced development group, the adept identification of ICWM-focused clinical inquiries, the nuanced integration of diverse evidence sources, and the detailed crafting of transparent, implementable recommendations. ConclusionsThis study concentrates on the most crucial and prevalent methodological issues in ICWM-CPG development, proposing a series of recommendations. These suggestions result from a multidisciplinary expert consensus, aiming to provide methodological guidance for ICWM-CPG developers, building upon the current foundational methodologies.

THE EFFECTS OF MODERATE TO HIGH-LOAD RESISTANCE TRAINING WITH BLOOD FLOW RESTRICTION IN HEALTHY ADULTS: A SYSTEMATIC REVIEW

INTRODUCTION AND AIMS Low-load resistance training (RT) with blood flow restriction (BFR; 20–40% of 1-repetition maximum [1RM]) increases muscle mass and strength comparably to unrestricted high-load RT. As healthy populations are not limited to low-loads, some researchers have also examined whether the adaptations to high-load RT could be enhanced with BFR, though results are inconsistent. Therefore, we conducted a systematic review to investigate whether moderate to high-load resistance training (M-HL RT) with BFR increases muscle mass or strength more than the equivalent training without BFR. METHODS Studies involving M-HL RT (≥60% 1RM) with BFR applied during exercise sets or rest intervals were included. The following databases were searched: PubMed, Web of Science, Scopus, ScienceDirect, ProQuest Central, and Google Scholar. Two researchers independently screened the titles and abstracts for eligibility based on the inclusion and exclusion criteria. The full texts of included studies were then independently screened by two researchers. Conflicts were resolved by a third researcher. Following screening, study and participant characteristics, intervention protocol for each group and outcome measures were extracted for each included study. RESULT Ten studies met the criteria for inclusion in this review. All included studies measured muscle strength, with only three reporting greater strength increases after M-HL RT with BFR compared to equivalent training without BFR. Five studies assessed muscle mass, with four reporting similar increases after M-HL RT with and without BFR. One observed a smaller increase in mass after M-HL RT with BFR than without. CONCLUSION Most studies did not observe additional benefit of applying BFR during M-HL RT for muscle strength or mass. Studies which did report benefits of BFR may be limited by methodological issues, impacting the applicability of their findings. Overall, this review does not support using BFR during M-HL RT for additional improvements in muscle strength or mass.

The Emergence of Interdisciplinary Environmental History

With the efflorescence of palaeoscientific approaches to the past, historians have been confronted with a wealth of new evidence on both human and natural phenomena, from human disease and migration to landscape change and climate. These new data require a rewriting of our narratives of the past, questioning what constitutes an authoritative historical source and who is entitled to recount history to contemporary societies. Humanities-based historical inquiry must embrace this new evidence, but to do so historians need to engage with it critically, just as they do with textual and material sources. This article highlights the most vital methodological issues, ranging from the spatiotemporal scales and heterogeneity of the new evidence to the new roles attributed to quantitative methods and the place of scientific data in narrative construction. It considers areas of study where the palaeosciences have “intruded” into fields and subjects previously reserved for historians, especially socioeconomic, climate, and environmental history. The authors argue that active engagement with new approaches is urgently needed if historians want to contribute to our evolving understanding of the challenges of the Anthropocene.

Near-Infrared Spectroscopy (NIRS) in the Assessment of Cerebral Tissue Oxygenation (rSO2): Methodological Issues and Dilemmas

Introduction: Monitoring cerebral perfusion in patients with brain injury is a major clinical challenge. Monitoring cerebral oxygenation (rSO2) via NIRS was introduced in the early 1980s, and many clinicians believed it to be a valuable method for assessing cerebral perfusion and subsequent measures to optimize cerebral flow. The main problem with the use of NIRS is the presence of intermediate structures—the skin, skull, meninges, cerebrospinal fluid—and their influence on the test result. Therefore, it seems that NIRS assessment performed on a patient during brain death can give an idea of the magnitude of the influence of these intermediate structures on the monitoring result. Case presentation: We present a case study of cerebral oxygenation measurements in a patient undergoing a brain death diagnostic procedure. A clinical situation in which cerebral blood flow is stopped can give an idea of the specificity of this method, in particular of the influence of intermediate structures on the monitoring result. In this case, the result obtained using NIRS is increased by the patient’s oxygenation before the apnea test. The influence of chromophores in the tissues surrounding the CNS and reflections and scattering of the light wave spectrum have a very significant effect on the final result of cerebral saturation measurement. Discussion: The majority of observations in existing research describing changes in cerebral perfusion or its optimization may be burdened by the problem described here, i.e., by the significant influence of measured intermediate structure oxygenation. The specificity of NIRS in assessing cerebral perfusion requires careful analysis. The therapeutic implications of monitoring cerebral oxygenation with NIRS are of great importance, and based on the example presented and the literature provided, this method should be used with caution. It has been shown that in a patient with brain death, the result of NIRS oxygenation measurements depends on the structures surrounding the brain.

Family Language Policy

This commentary outlines the key contributions of the issue. Addressing various language attitudes and ideologies held by family members, the commentary highlights the major themes of the collected articles, addressing important issues in the maintenance of home languages and development of minoritised languages as well as interactions between families and the wider society. In particular, it looks into why heritage and minoritised languages are difficult to maintain and develop in multilingual contexts. The commentary emphasises how families constantly interact with broader sociocultural, sociohistorical, and sociopolitical contexts and outlines the agentive role of family members in accommodating or resisting language change. It highlights the key topics, theoretical contributions, and methodological issues in this issue.

Conceptual and Methodological Barriers to Understanding Long COVID

This article focuses on individuals with Long COVID after contracting SARS-CoV-2. Although some patients have complications such as diabetes mellitus or tissue damage to the heart or lungs as a result of SARS-CoV-2 infection, our research focuses on individuals who have persistent symptoms that are not consistent with major organ dysfunction. The current article reviews methodological and conceptual issues that need to be considered in the development and use of a case definition for Long COVID and discusses the significance of appropriately phrasing questions assessing symptoms, specifying thresholds for when to count a symptom, determining how many symptoms should be required for a diagnosis, assessing symptoms over time, using multiple assessment modalities, and differentiating symptomatology from functionality. Dealing with these issues, particularly triangulating data from multiple sources, allows investigators to develop a more reliable and valid way to assess Long COVID.

Methodology for Assessing the Quality of the Economic Space of the Region

Introduction. The relevance of the topic is determined by the need for theoretical and methodological justification and practical study of the problem of measuring the quality of the economic space of Russian regions and its influence on the development of the regional economy. The absence of this type of research increases the significance of this work. The purpose of the study is to develop methodological issues for measuring the quality of the regional economic space and substantiate the methodology for its integral assessment. Materials and Methods. The object of the study was Russian regions and their socio-economic state. The authorsʼ methodology is based on system analysis, econometric modeling using indices calculated on panel data for regions, as well as the method of expert surveys. To obtain quantitative estimates of the economic space based on Rosstat data, an information base was created for 85 regions of the Russian Federation, covering the period from 2007 to 2021. A typology of Russian regions has been carried out according to the level of the integral indicator of the quality of the economic space. Results. An original methodological approach is proposed, based on a systemic assessment of the total influence of a set of factors on the quality of the regional economic space. Within the framework of this approach, a methodology for measuring the quality of the economic space of a region has been developed and tested. Regions were grouped according to the level of the economic space; based on econometric modeling and empirical data, the influence of the economic space on the gross regional product per capita of Russian territories was established. Discussion and Conclusion. It is proposed to carry out a relative assessment of the quality of the economic space using a system of indicators grouped into three blocks: “input”, “process”, “output”. Such a structure of indicators is capable of systematically reflecting the strengths and weaknesses of a particular region, the sources of regional spatial dynamics, and therefore can be used for an integral assessment of the level of development of territories. The results of the study can be used in the development and implementation of regional economic policy, and will also be useful to specialists and government officials involved in the development of strategic directions for improving the territorial structure of the Russian Federation.

Forensic Aftercare Facilities and Their Impact on the Releasability of Persons Who Committed Sexual Offenses: A Three Group Comparison.

Partly due to a lack of release options for individuals who committed sexual offenses, forensic follow-up treatment has been strengthened latest since 2007. The current study investigates whether the foundation of a professionalized follow-up-treatment has actually improved release options for individuals who committed sexual offenses. Thus, the aim of the present study was to assess the difference in criminogenic needs and recidivism relevant characteristics (e.g., index offense, criminal history, psychiatric diagnoses and risk assessment) between three groups who had been released from forensic psychiatry at different times or under different outpatient follow-up modalities: (1) individuals released prior the foundation of professionalized follow-up-treatment, (2) individuals released after the foundation and received treatment, and (3) individuals released after the foundation but not receiving this special treatment. It was found that with the availability of professionalized forensic followup treatment, persons with higher scores in common risk assessment tools and a longer duration of implacement had been released. Indeed, this indicates an increased risk tolerance among decision makers. However, it was not those who were released after the foundation of the professionalized forensic follow-up treatment but without this specific treatment who showed the lowest initial risk, but those who were released prior to the foundation. Results are discussed in terms of possible explanations and methodological issues.

Poor evidence for poor R wave progression in coronary disease: A scoping review

BackgroundPoor R wave progression (PRWP) and reversed R wave progression (RRWP) have long been noted in electrocardiograms as potential indicators of anterior wall fibrosis or chronic coronary artery disease; however, the quantity and quality of evidence supporting these associations warrants closer examination. ObjectiveThe aim of this scoping review is to assess the breadth of evidence regarding the diagnostic significance of PRWP and RRWP, explore the extent of research, study populations and methodologies, and the presence of gaps in knowledge regarding these electrocardiographic phenomena and their association with coronary diseases. DesignWe conducted a comprehensive search across PubMed, Web of Science, and Scopus, covering literature on PRWP or RRWP in the context of myocardial infarction, ischemia, or fibrosis from any time period and in any language. ResultsA total of 20 studies were included in this review, highlighting the severe paucity of data. No high-quality accuracy studies have been identified, and existing research suffers from methodological issues, in particular selection bias. Prevalence and prognostic studies showed significant heterogeneity in terms of definitions and outcomes, which contributes to an alarming risk of bias. ConclusionsThe lack of solid evidence for PRWP and RRWP as diagnostic markers for acute and chronic coronary artery disease necessitates caution in clinical interpretation. Future research should focus on well-designed case-control studies to clarify the diagnostic accuracy of these markers. Until robust evidence is available, the reliance on PRWP/RRWP for diagnosing anterior infarction should be discouraged, reflecting a gap between clinical practice and evidence-based medicine.

Charting User Experience in Physical Human-Robot Interaction

Robots increasingly interact with humans through touch, where people are touching or being touched by robots. Yet, little is known about how such interactions shape a user’s experience. To inform future work in this area, we conduct a systematic review of 44 studies on physical human-robot interaction (pHRI). Our review examines the parameters of the touch (e.g., the role of touch, location), the experimental variations used by researchers, and the methods used to assess user experience. We identify five facets of user experience metrics from the questionnaire items and data recordings for pHRI studies. We highlight gaps and methodological issues in studying pHRI and compare user evaluation trends with the Human–Computer Interaction (HCI) literature. Based on the review, we propose a conceptual model of the pHRI experience. The model highlights the components of such touch experiences to guide the design and evaluation of physical interactions with robots and inform future user experience questionnaire development.

Multicomponent perioperative interventions to improve outcomes for frail patients: a systematic review

BackgroundPreoperative frailty is associated with increased risk of adverse outcomes. In 2017, McIsaac and colleagues’ systematic review found that few interventions improved outcomes in this population and evidence was low-quality. We aimed to systematically review the evidence for multicomponent perioperative interventions in frail patients that has emerged since McIsaac et al.’s review.MethodsPUBMED, EMBASE, Cochrane, and CINAHL databases were searched for English-language studies published since January 1, 2016, that evaluated multicomponent perioperative interventions in patients identified as frail. Quality was assessed using the National Institute of Health Quality Assessment Tool. A narrative synthesis of the extracted data was conducted.ResultsOf 2835 articles screened, five studies were included, all of which were conducted in elective oncologic gastrointestinal surgical populations. Four hundred and thirteen patients were included across the five studies and the mean/median age ranged from 70.1 to 87.0 years. Multicomponent interventions were all applied in the preoperative period. Two studies also applied interventions postoperatively. All interventions addressed exercise and nutritional domains with variability in timing, delivery, and adherence. Multicomponent interventions were associated with reduced postoperative complications, functional deterioration, length of stay, and mortality. Four studies reported on patient-centred outcomes. The quality of evidence was fair.ConclusionsThis systematic review provides evidence that frail surgical patients undergoing elective oncologic gastrointestinal surgery may benefit from targeted multicomponent perioperative interventions. Yet methodological issues and substantial heterogeneity of the interventions precludes drawing clear conclusions regarding the optimal model of care. Larger, low risk of bias studies are needed to evaluate optimal intervention delivery, effectiveness in other populations, implementation in health care settings and ascertain outcomes of importance for frail patients and their carers.

Methodological issues of retrospective surveys for measuring mortality of highly clustered diseases: case study of the 2014–16 Ebola outbreak in Bo District, Sierra Leone

ABSTRACT Background There is a lack of empirical data on design effects (DEFF) for mortality rate for highly clustered data such as with Ebola virus disease (EVD), along with a lack of documentation of methodological limitations and operational utility of mortality estimated from cluster-sampled studies when the DEFF is high. Objectives The objectives of this paper are to report EVD mortality rate and DEFF estimates, and discuss the methodological limitations of cluster surveys when data are highly clustered such as during an EVD outbreak. Methods We analysed the outputs of two independent population-based surveys conducted at the end of the 2014–2016 EVD outbreak in Bo District, Sierra Leone, in urban and rural areas. In each area, 35 clusters of 14 households were selected with probability proportional to population size. We collected information on morbidity, mortality and changes in household composition during the recall period (May 2014 to April 2015). Rates were calculated for all-cause, all-age, under-5 and EVD-specific mortality, respectively, by areas and overall. Crude and adjusted mortality rates were estimated using Poisson regression, accounting for the surveys sample weights and the clustered design. Results Overall 980 households and 6,522 individuals participated in both surveys. A total of 64 deaths were reported, of which 20 were attributed to EVD. The crude and EVD-specific mortality rates were 0.35/10,000 person-days (95%CI: 0.23–0.52) and 0.12/10,000 person-days (95%CI: 0.05–0.32), respectively. The DEFF for EVD mortality was 5.53, and for non-EVD mortality, it was 1.53. DEFF for EVD-specific mortality was 6.18 in the rural area and 0.58 in the urban area. DEFF for non-EVD-specific mortality was 1.87 in the rural area and 0.44 in the urban area. Conclusion Our findings demonstrate a high degree of clustering; this contributed to imprecise mortality estimates, which have limited utility when assessing the impact of disease. We provide DEFF estimates that can inform future cluster surveys and discuss design improvements to mitigate the limitations of surveys for highly clustered data.

METHODOLOGY OF TEACHING ELEMENTS OF COMBINATORICS AT THE COMPREHENSIVE SECONDARY SCHOOL

The object of the study is the elements of combinatorics at the comprehensive secondary school. The aim of the article is to improve the methodological system of teaching elements of combinatorics at the comprehensive secondary school. The article discusses methodological issues and problems of studying combinatorics elements in the process of teaching mathematics. The methodological features of studying combinatorics elements at the comprehensive secondary school are identified and characterized, their role in the course of mathematics from the point of view of improving the effectiveness of learning is considered. The methods and methodical techniques of teaching combinatorial material, which were previously tested in our educational process, are presented. The possibilities and expediency of their application in connection with the age peculiarities of students are substantiated. Methodological guidelines for teaching individual topics of combinatorics are given. Within the framework of teaching each topic, interesting tasks of applied significance are presented. Effective methods of their solution are given. The presented tasks have been tested for years in our teaching practice. In the process of teaching the elements of combinatorics, methods of cooperative learning, mathematical modeling, graphical modeling, coding, methods that promoting inter- and intra-subject connections were used.

Mobility-oriented measurements of people's exposure to outdoor artificial light at night (ALAN) and the uncertain geographic context problem (UGCoP).

Advanced nighttime light (NTL) remote sensing techniques enable the large-scope epidemiological investigations of people's exposure to outdoor artificial light at night (ALAN) and its health effects. However, multiple uncertainties remain in the measurements of people's exposure to outdoor ALAN, including the representations of outdoor ALAN, the contextual settings of exposure measurements, and measurement approaches. Non-exposed but included outdoor ALAN and causally irrelevant outdoor ALAN may manifest as contextual errors, and these uncertain contextual errors may lead to biased measurements and erroneous interpretations when modeling people's health outcomes. In this study, we systematically investigated outdoor ALAN exposure measurements in different geographic contexts using either residence-based or mobility-oriented measurements, different spatial scales, and multiple NTL data sources. Based on the GPS data collected from 208 participants in Hong Kong, outdoor ALAN exposures were measured from NTL imagery at 10 m, 130 m, and 500 m spatial resolutions using in-situ methods or 100 m, 300 m, and 500 m buffer zone averaging. Descriptive analysis, multiple t-tests, and logistic regression were employed to examine the differences between outdoor ALAN exposure measurements using various contextual settings and their effects on modeling people's overall health. Our results confirmed that different contextual settings may lead to significantly different outdoor ALAN exposure measurements. Our results also confirmed that contextual errors may lead to erroneous conclusions when using improper contextual settings to model people's overall health. Consequentially, we suggest measuring people's exposure to outdoor ALAN using the mobility-oriented approach, NTL representation with the high spatial resolution, and a very small buffer zone as a contextual unit to derive outdoor ALAN exposure. This study articulates essential methodological issues induced by uncertainties in outdoor ALAN exposure measurements and can provide essential implications and suggestions for a broad scope of studies that need accurate outdoor ALAN exposure measurements.

A Dual State in Turkey?

AbstractIn research on authoritarianism in Turkey and beyond, there is a growing interest in Ernst Fraenkel’s concept of the dual state from the Nazi era. However, upon closer inspection, these articles lack a systematic application and implementation of Fraenkel’s concept. Mostly, there is no discussion of the strengths and weaknesses of such a ‘diachronic’ conceptual transfer. This case study therefore puts particular emphasis on the methodological issues and on the possibilities and limitations of an ‘updated’ application. As a result, it turns out that Fraenkel’s categories are useful tools to trace how the Turkish administration and judiciary are reorganized along a logic of prerogative power. Fraenkel’s state-centred approach can thus contribute to close a gap left by alternative approaches. However, among the weaknesses even of Dreier and Meierhenrich’s supplement is that the time dimension was, respectively is, not sufficiently taken into account. Dual state structures can be more sustainable than originally assumed by Fraenkel.